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A significant increase in total plasma LCR levels at week 9 was observed in the LCR group (8.35 mol/L, 95% CI 5.53, 11.1) and not in the PLA group (0.45 mol/L, 95% CI -2.48, 3.40)

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(Reference Gayatri, Kumar and Kumar28) , participants were not randomly assigned to the intervention and control groups, and seven studies described an allocation concealment method (Reference Hassan, Alalfy and Hassan18,Reference Badawy, El Nashar and El Totongy20Reference Hashim, Anwar and El-Fatah22,Reference Elgindy, El-Huseiny and Mostafa23,Reference Ghomian, Khadem and Moeindarbari5,Reference Maged, Elsawah and Abdelhafez8)

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